Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-somatic	3.32e-02	2.00e-01	9.14e-03	3.78e-10
BRCA-somatic Exclusive	FullCohort_Controls_AllCoreGenes	3.30e-03	4.47e-03	5.94e-15	4.99e-06
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-somatic Exclusive	7.49e-02	3.05e-01	3.91e-02	5.33e-10
BRCA-somatic Exclusive	FullCohort_Controls_AllCoreGenes Exclusive	3.00e-03	3.82e-03	5.40e-15	3.16e-06
FullCohort_Controls_AllCoreGenes Exclusive	Overlap	1.93e-01	1.93e-01	1.93e-01	1.97e-01
BRCA-somatic Exclusive	Overlap	8.41e-03	8.41e-03	8.92e-04	5.11e-03
Overlap	Exclusives	7.11e-08	1.02e-03	1.12e-60	1.42e-09



Evaluating how well FullCohort_Controls_AllCoreGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-somatic	0.82	-2.01	1.93	-0.79	7.06
BRCA-somatic Exclusive	FullCohort_Controls_AllCoreGenes	0.57	1.43	-1.09	-0.29	3.43
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-somatic Exclusive	0.82	-2.07	2.33	-0.74	6.93
BRCA-somatic Exclusive	FullCohort_Controls_AllCoreGenes Exclusive	0.56	1.15	-1.24	-0.24	3.86
FullCohort_Controls_AllCoreGenes Exclusive	Overlap	0.79	-0.94	0.40	-0.76	2.17
BRCA-somatic Exclusive	Overlap	0.95	-0.27	3.14	2.54	3.07
Overlap	Exclusives	0.62	2.50	1.71	0.13	7.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-somatic	0.01	-2.55	3.67	-1.40	8.92
BRCA-somatic Exclusive	FullCohort_Controls_AllCoreGenes	0.02	1.10	1.67	0.38	4.18
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-somatic Exclusive	0.01	-2.52	2.79	-1.44	1.25
BRCA-somatic Exclusive	FullCohort_Controls_AllCoreGenes Exclusive	0.02	0.58	0.53	0.61	4.60
FullCohort_Controls_AllCoreGenes Exclusive	Overlap	0.00	-1.31	4.71	-1.16	2.46
BRCA-somatic Exclusive	Overlap	0.02	1.29	140.15	52.94	47.99
Overlap	Exclusives	0.03	7.11	6.20	0.84	13.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FullCohort_Controls_AllCoreGenes Exclusive	274	273	GBA3
BRCA-somatic Exclusive	33	33	
Overlap	4	4