Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-gwas	1.53e-06	7.70e-01	3.67e-04	3.18e-04
BRCA-gwas Exclusive	FullCohort_Controls_AllCoreGenes	3.67e-03	1.65e-01	4.66e-07	5.09e-04
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-gwas Exclusive	1.12e-06	7.13e-01	2.69e-04	6.62e-04
BRCA-gwas Exclusive	FullCohort_Controls_AllCoreGenes Exclusive	1.69e-03	1.08e-01	1.41e-06	1.93e-03
FullCohort_Controls_AllCoreGenes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.07e-03
BRCA-gwas Exclusive	Overlap	5.17e-01	7.52e-01	1.18e-02	1.03e-02
Overlap	Exclusives	2.25e-04	1.23e-03	4.47e-56	4.34e-08



Evaluating how well FullCohort_Controls_AllCoreGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-gwas	0.58	-2.37	-0.27	-1.19	3.60
BRCA-gwas Exclusive	FullCohort_Controls_AllCoreGenes	0.56	-0.54	-1.64	-0.20	4.52
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-gwas Exclusive	0.58	-2.68	-0.72	-1.56	3.37
BRCA-gwas Exclusive	FullCohort_Controls_AllCoreGenes Exclusive	0.56	-0.63	-1.62	-0.19	3.33
FullCohort_Controls_AllCoreGenes Exclusive	Overlap	0.97	0.94	1.69	0.88	2.50
BRCA-gwas Exclusive	Overlap	0.97	0.32	1.51	0.98	2.25
Overlap	Exclusives	0.57	-0.10	-2.58	-0.46	5.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-gwas	0.01	-2.49	-0.00	-1.10	4.86
BRCA-gwas Exclusive	FullCohort_Controls_AllCoreGenes	0.02	-0.19	1.31	1.09	4.24
FullCohort_Controls_AllCoreGenes Exclusive	BRCA-gwas Exclusive	0.01	-2.64	-0.21	-1.18	2.23
BRCA-gwas Exclusive	FullCohort_Controls_AllCoreGenes Exclusive	0.02	-0.35	0.42	0.37	3.44
FullCohort_Controls_AllCoreGenes Exclusive	Overlap	0.00	-0.14	10.14	0.48	2.75
BRCA-gwas Exclusive	Overlap	0.02	2.50	0.22	15.26	98.18
Overlap	Exclusives	0.04	3.33	8.87	1.80	15.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FullCohort_Controls_AllCoreGenes Exclusive	276	275	GBA3
BRCA-gwas Exclusive	171	171	
Overlap	2	2