Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eaml	gp2maybe	1.12e-01	6.10e-02	1.25e-01	6.09e-03
gp2maybe	eaml	1.81e-03	4.79e-02	2.05e-15	1.65e-01



Evaluating how well eaml genes are linked to gp2maybe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml	gp2maybe	0.83	2.18	2.80	2.08	3.14
gp2maybe	eaml	0.53	2.43	2.14	1.33	1.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml	gp2maybe	0.00	3.81	3.40	3.91	1.12
gp2maybe	eaml	0.01	3.79	1.97	3.24	3.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eaml	167	167	
gp2maybe	6	6