Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi	gp2maybe	6.35e-01	6.93e-01	7.29e-01	2.73e-01
gp2maybe	epi	1.53e-01	2.76e-01	4.75e-08	4.34e-01



Evaluating how well epi genes are linked to gp2maybe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	gp2maybe	0.67	0.07	0.57	0.34	1.51
gp2maybe	epi	0.50	1.53	1.20	0.72	0.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi	gp2maybe	0.00	0.24	0.86	0.50	1.00
gp2maybe	epi	0.01	0.18	0.61	0.24	0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi	127	126	AC010255.3
gp2maybe	6	6