Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
109_2method Exclusive	GS25	3.91e-08	7.55e-09	3.91e-10	3.18e-11
GS25 Exclusive	109_2method	1.35e-02	5.48e-02	3.46e-03	1.23e-02
109_2method Exclusive	GS25 Exclusive	1.18e-05	2.65e-07	2.54e-06	1.09e-07
GS25 Exclusive	109_2method Exclusive	1.70e-01	2.82e-01	4.83e-02	6.90e-02
109_2method Exclusive	Overlap	9.76e-04	5.01e-03	3.78e-05	2.97e-06
GS25 Exclusive	Overlap	2.09e-13	2.10e-07	2.09e-13	2.39e-10
Overlap	Exclusives	4.21e-04	7.45e-05	1.22e-10	1.07e-05



Evaluating how well 109_2method genes are linked to GS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_2method Exclusive	GS25	0.85	3.00	6.52	3.23	5.92
GS25 Exclusive	109_2method	0.59	2.56	2.21	2.62	3.48
109_2method Exclusive	GS25 Exclusive	0.81	2.71	4.79	2.54	4.61
GS25 Exclusive	109_2method Exclusive	0.57	1.88	1.41	1.67	2.32
109_2method Exclusive	Overlap	0.96	2.85	3.68	3.13	4.16
GS25 Exclusive	Overlap	0.99	3.64	3.19	3.60	3.81
Overlap	Exclusives	0.62	2.80	3.73	3.07	4.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_2method Exclusive	GS25	0.02	11.32	37.76	13.06	21.22
GS25 Exclusive	109_2method	0.02	23.34	11.66	19.08	13.13
109_2method Exclusive	GS25 Exclusive	0.01	9.47	41.69	7.28	9.68
GS25 Exclusive	109_2method Exclusive	0.01	8.07	3.69	6.07	3.50
109_2method Exclusive	Overlap	0.01	9.06	15.13	17.17	4.38
GS25 Exclusive	Overlap	0.07	241.38	112.92	266.49	181.13
Overlap	Exclusives	0.06	36.69	76.70	72.13	94.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
109_2method Exclusive	103	102	RFPL2
GS25 Exclusive	19	19	
Overlap	6	6