Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PathwayEAML	EAML	1.64e-09	2.98e-01	8.33e-05	9.21e-01
EAML	PathwayEAML	2.29e-01	1.09e-01	6.84e-01	6.72e-03



Evaluating how well PathwayEAML genes are linked to EAML genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PathwayEAML	EAML	0.51	-2.95	-1.62	-1.45	0.28
EAML	PathwayEAML	0.59	-0.44	-2.06	-0.23	3.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PathwayEAML	EAML	0.01	-1.62	-0.88	-0.34	0.23
EAML	PathwayEAML	0.01	-0.28	-1.28	0.03	4.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PathwayEAML	125	124	TFDP2
EAML	128	128