Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
216 control Exclusive	GS25	2.34e-06	2.20e-07	3.34e-09	4.11e-09
GS25 Exclusive	216 control	3.25e-04	7.04e-03	1.56e-05	6.29e-05
216 control Exclusive	GS25 Exclusive	5.66e-04	5.76e-05	3.53e-05	1.59e-05
GS25 Exclusive	216 control Exclusive	5.14e-03	3.30e-02	2.14e-04	3.23e-04
216 control Exclusive	Overlap	1.15e-04	4.14e-04	1.82e-07	1.77e-08
GS25 Exclusive	Overlap	1.38e-11	1.34e-07	8.35e-13	1.62e-09
Overlap	Exclusives	2.39e-04	9.54e-06	1.59e-16	6.69e-08



Evaluating how well 216 control genes are linked to GS25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216 control Exclusive	GS25	0.84	3.07	5.16	3.03	6.54
GS25 Exclusive	216 control	0.60	3.62	3.39	2.53	5.35
216 control Exclusive	GS25 Exclusive	0.80	2.65	4.51	2.44	4.51
GS25 Exclusive	216 control Exclusive	0.59	2.97	2.68	2.67	4.37
216 control Exclusive	Overlap	0.98	2.83	3.29	3.32	4.30
GS25 Exclusive	Overlap	0.99	4.01	3.93	2.96	3.83
Overlap	Exclusives	0.61	2.08	4.34	3.08	6.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
216 control Exclusive	GS25	0.02	8.95	22.86	12.55	3.24
GS25 Exclusive	216 control	0.02	10.69	8.41	8.65	15.86
216 control Exclusive	GS25 Exclusive	0.01	10.13	22.04	5.46	4.63
GS25 Exclusive	216 control Exclusive	0.02	5.57	5.61	5.64	6.02
216 control Exclusive	Overlap	0.01	8.84	13.51	14.67	7.05
GS25 Exclusive	Overlap	0.07	206.03	131.60	163.35	4.09
Overlap	Exclusives	0.05	19.67	41.69	32.07	51.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
216 control Exclusive	210	209	RFPL2
GS25 Exclusive	19	19	
Overlap	6	6