Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_PD Exclusive	gwas	5.86e-01	8.16e-01	4.42e-05	2.67e-03
gwas Exclusive	fcs_PD	4.61e-01	3.10e-03	3.05e-17	9.36e-22
fcs_PD Exclusive	gwas Exclusive	5.89e-01	7.58e-01	8.02e-05	4.70e-03
gwas Exclusive	fcs_PD Exclusive	6.51e-01	4.44e-03	3.34e-17	4.33e-21
fcs_PD Exclusive	Overlap	9.81e-01	8.35e-01	3.36e-01	6.44e-01
gwas Exclusive	Overlap	6.29e-02	4.31e-02	1.64e-02	1.96e-02
Overlap	Exclusives	6.19e-03	7.50e-02	2.66e-18	9.17e-28



Evaluating how well fcs_PD genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD Exclusive	gwas	0.63	1.56	1.19	1.33	3.91
gwas Exclusive	fcs_PD	0.65	1.49	3.55	2.82	10.89
fcs_PD Exclusive	gwas Exclusive	0.64	1.38	1.00	1.36	3.59
gwas Exclusive	fcs_PD Exclusive	0.64	0.90	3.26	2.79	10.52
fcs_PD Exclusive	Overlap	0.61	0.78	1.19	0.62	1.08
gwas Exclusive	Overlap	0.72	2.57	2.36	1.87	2.69
Overlap	Exclusives	0.65	1.68	3.27	1.71	12.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD Exclusive	gwas	0.01	2.03	0.53	2.61	2.77
gwas Exclusive	fcs_PD	0.04	1.59	4.14	4.01	14.26
fcs_PD Exclusive	gwas Exclusive	0.01	2.78	0.65	3.22	2.09
gwas Exclusive	fcs_PD Exclusive	0.03	0.32	2.39	2.90	11.26
fcs_PD Exclusive	Overlap	0.00	-0.74	-0.67	-0.23	0.21
gwas Exclusive	Overlap	0.04	106.96	180.86	47.65	107.29
Overlap	Exclusives	0.04	2.90	5.29	2.92	12.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_PD Exclusive	426	426	
gwas Exclusive	68	67	CASC16
Overlap	9	9