Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_PD Exclusive	singleton	3.32e-01	1.32e-01	7.16e-07	4.64e-07
singleton Exclusive	fcs_PD	1.28e-02	5.12e-01	2.17e-26	1.89e-17
fcs_PD Exclusive	singleton Exclusive	6.14e-01	2.83e-01	1.89e-05	2.61e-06
singleton Exclusive	fcs_PD Exclusive	7.70e-03	5.94e-01	1.28e-26	1.07e-16
fcs_PD Exclusive	Overlap	2.05e-01	2.49e-02	2.76e-03	6.21e-02
singleton Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	3.86e-08	6.42e-03	1.11e-45	1.06e-23



Evaluating how well fcs_PD genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD Exclusive	singleton	0.84	2.81	3.22	2.73	5.76
singleton Exclusive	fcs_PD	0.64	1.22	1.75	1.58	10.11
fcs_PD Exclusive	singleton Exclusive	0.83	2.64	2.70	2.32	6.03
singleton Exclusive	fcs_PD Exclusive	0.64	0.64	1.39	1.49	10.31
fcs_PD Exclusive	Overlap	0.88	1.33	1.94	1.37	1.63
singleton Exclusive	Overlap	1.00	2.21	3.62	2.81	2.60
Overlap	Exclusives	0.66	1.51	2.91	1.88	12.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD Exclusive	singleton	0.01	0.09	-3.87	1.51	10.09
singleton Exclusive	fcs_PD	0.04	3.08	3.73	4.71	14.14
fcs_PD Exclusive	singleton Exclusive	0.00	0.17	-4.16	1.91	2.69
singleton Exclusive	fcs_PD Exclusive	0.04	1.71	1.97	3.48	11.81
fcs_PD Exclusive	Overlap	0.00	0.72	1.24	0.41	-0.05
singleton Exclusive	Overlap	0.03	47.51	479.62	166.99	119.30
Overlap	Exclusives	0.04	2.42	4.94	2.44	13.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_PD Exclusive	433	433	
singleton Exclusive	19	19	
Overlap	2	2