Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_Lbd	adIsmael	2.79e-01	1.63e-01	3.39e-01	3.33e-01
adIsmael	2mcs_Lbd	3.85e-01	6.15e-01	2.88e-04	7.08e-01



Evaluating how well 2mcs_Lbd genes are linked to adIsmael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_Lbd	adIsmael	0.57	-1.20	-2.42	-1.13	1.17
adIsmael	2mcs_Lbd	0.52	1.57	0.57	0.34	0.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_Lbd	adIsmael	0.00	-0.10	-0.00	-0.10	0.74
adIsmael	2mcs_Lbd	0.01	-0.19	-0.26	-0.17	-0.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_Lbd	127	126	PNMA6F
adIsmael	14	14