Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_Lbd Exclusive	lbd_gs	1.78e-01	4.31e-01	1.41e-01	5.01e-03
lbd_gs Exclusive	2mcs_Lbd	4.51e-04	2.19e-02	7.69e-27	1.02e-02
2mcs_Lbd Exclusive	lbd_gs Exclusive	3.62e-01	8.36e-01	3.20e-01	4.56e-02
lbd_gs Exclusive	2mcs_Lbd Exclusive	3.91e-04	4.37e-02	5.00e-23	3.76e-02
2mcs_Lbd Exclusive	Overlap	5.55e-01	5.17e-01	6.44e-01	1.86e-01
lbd_gs Exclusive	Overlap	9.85e-04	9.85e-05	1.48e-03	9.85e-04
Overlap	Exclusives	3.17e-02	8.57e-02	1.19e-24	5.14e-02



Evaluating how well 2mcs_Lbd genes are linked to lbd_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_Lbd Exclusive	lbd_gs	0.84	1.28	1.54	1.03	3.06
lbd_gs Exclusive	2mcs_Lbd	0.56	5.09	2.73	1.89	2.11
2mcs_Lbd Exclusive	lbd_gs Exclusive	0.83	1.26	1.76	1.08	2.14
lbd_gs Exclusive	2mcs_Lbd Exclusive	0.55	5.50	2.60	1.77	1.91
2mcs_Lbd Exclusive	Overlap	0.86	0.32	-0.08	0.28	1.75
lbd_gs Exclusive	Overlap	0.99	3.18	2.66	2.04	2.42
Overlap	Exclusives	0.55	1.03	2.47	1.32	2.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_Lbd Exclusive	lbd_gs	0.00	2.01	21.78	2.44	11.79
lbd_gs Exclusive	2mcs_Lbd	0.01	5.40	3.37	1.26	3.15
2mcs_Lbd Exclusive	lbd_gs Exclusive	0.00	1.62	4.66	1.14	1.04
lbd_gs Exclusive	2mcs_Lbd Exclusive	0.01	6.05	1.74	1.42	1.08
2mcs_Lbd Exclusive	Overlap	0.00	1.61	5.34	1.18	0.33
lbd_gs Exclusive	Overlap	0.01	25.99	71.95	35.06	20.03
Overlap	Exclusives	0.01	4.47	3.70	1.16	3.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_Lbd Exclusive	125	124	PNMA6F
lbd_gs Exclusive	4	4	
Overlap	2	2