Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cau Exclusive	gwas	9.74e-01	9.48e-01	6.08e-05	5.99e-02
gwas Exclusive	cau	5.11e-01	2.90e-01	1.04e-05	1.38e-12
cau Exclusive	gwas Exclusive	9.92e-01	9.48e-01	6.16e-05	5.34e-02
gwas Exclusive	cau Exclusive	3.88e-01	2.64e-01	3.14e-05	6.09e-12
cau Exclusive	Overlap	7.52e-01	9.17e-01	5.17e-01	5.55e-01
gwas Exclusive	Overlap	7.92e-01	6.10e-01	8.51e-01	9.98e-01
Overlap	Exclusives	1.23e-01	5.50e-01	1.82e-18	4.22e-16



Evaluating how well cau genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cau Exclusive	gwas	0.59	-0.01	-0.51	0.45	3.40
gwas Exclusive	cau	0.70	-0.36	1.06	1.58	8.09
cau Exclusive	gwas Exclusive	0.59	0.12	-0.39	0.64	2.93
gwas Exclusive	cau Exclusive	0.71	-0.53	1.19	1.54	6.93
cau Exclusive	Overlap	0.69	-1.17	-0.48	0.28	0.96
gwas Exclusive	Overlap	0.50	-1.34	-0.82	-0.80	-0.01
Overlap	Exclusives	0.68	0.72	0.45	0.96	8.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cau Exclusive	gwas	0.01	0.04	-1.43	1.61	1.34
gwas Exclusive	cau	0.01	-1.03	-0.42	1.40	4.22
cau Exclusive	gwas Exclusive	0.01	0.19	-1.24	1.72	1.21
gwas Exclusive	cau Exclusive	0.01	-1.24	-0.26	1.29	6.80
cau Exclusive	Overlap	0.00	-0.68	-0.56	-0.08	0.29
gwas Exclusive	Overlap	0.00	-0.54	-0.58	-0.42	-0.33
Overlap	Exclusives	0.02	-0.30	-0.91	0.09	7.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cau Exclusive	112	112	
gwas Exclusive	75	73	GPNMB;CASC16
Overlap	2	2