Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
caushy_lbd	AD-Ismael	3.75e-01	7.74e-02	8.08e-07	5.92e-06
AD-Ismael	caushy_lbd	1.60e-04	6.10e-01	1.29e-02	1.45e-10



Evaluating how well caushy_lbd genes are linked to AD-Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_lbd	AD-Ismael	0.84	0.99	2.86	1.87	4.10
AD-Ismael	caushy_lbd	0.71	-1.05	0.51	0.10	6.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_lbd	AD-Ismael	0.00	-0.28	-0.50	1.72	2.62
AD-Ismael	caushy_lbd	0.01	0.61	0.17	2.52	7.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
caushy_lbd	81	81	
AD-Ismael	14	14