Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
caushy_pd Exclusive	singleton	8.87e-01	8.25e-01	1.88e-05	5.25e-05
singleton Exclusive	caushy_pd	6.87e-02	4.38e-01	1.98e-08	1.32e-09
caushy_pd Exclusive	singleton Exclusive	9.36e-01	7.93e-01	3.56e-04	1.03e-03
singleton Exclusive	caushy_pd Exclusive	5.62e-02	7.05e-01	2.78e-08	2.14e-09
caushy_pd Exclusive	Overlap	2.31e-01	2.52e-01	2.49e-02	6.21e-02
singleton Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	5.91e-04
Overlap	Exclusives	4.74e-06	1.15e-04	2.96e-23	1.23e-17



Evaluating how well caushy_pd genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_pd Exclusive	singleton	0.80	0.97	1.52	2.06	4.64
singleton Exclusive	caushy_pd	0.66	0.25	0.67	1.35	7.19
caushy_pd Exclusive	singleton Exclusive	0.79	1.15	1.32	1.60	4.24
singleton Exclusive	caushy_pd Exclusive	0.66	-0.10	0.19	0.98	7.16
caushy_pd Exclusive	Overlap	0.87	1.51	1.48	1.48	2.05
singleton Exclusive	Overlap	1.00	2.47	3.27	2.86	2.51
Overlap	Exclusives	0.71	2.00	2.90	2.25	10.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_pd Exclusive	singleton	0.00	-0.17	-3.94	2.02	7.50
singleton Exclusive	caushy_pd	0.02	2.06	1.95	3.90	6.64
caushy_pd Exclusive	singleton Exclusive	0.00	0.06	-4.71	1.99	4.06
singleton Exclusive	caushy_pd Exclusive	0.01	0.66	0.86	2.62	4.62
caushy_pd Exclusive	Overlap	0.00	1.43	0.64	0.03	0.19
singleton Exclusive	Overlap	0.03	52.73	479.85	157.00	86.14
Overlap	Exclusives	0.02	4.35	8.21	4.52	13.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
caushy_pd Exclusive	159	159	
singleton Exclusive	19	19	
Overlap	2	2