Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
caushy_lbd	adIsmael	9.62e-01	2.85e-01	3.36e-02	3.30e-03
adIsmael	caushy_lbd	3.39e-04	5.52e-01	4.08e-03	8.62e-05



Evaluating how well caushy_lbd genes are linked to adIsmael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_lbd	adIsmael	0.75	-0.06	1.35	0.77	3.10
adIsmael	caushy_lbd	0.59	-0.94	-0.37	-0.38	4.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_lbd	adIsmael	0.00	-0.53	-1.43	-0.03	2.10
adIsmael	caushy_lbd	0.01	-0.49	-0.29	0.88	2.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
caushy_lbd	151	151	
adIsmael	14	14