Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
caushy_lbd Exclusive	lbdgs	5.28e-01	7.42e-01	4.05e-02	1.40e-02
lbdgs Exclusive	caushy_lbd	2.34e-01	9.60e-02	5.32e-24	2.87e-08
caushy_lbd Exclusive	lbdgs Exclusive	9.10e-01	5.94e-01	2.00e-01	5.33e-02
lbdgs Exclusive	caushy_lbd Exclusive	2.02e-01	7.10e-02	5.17e-24	1.41e-07
caushy_lbd Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
lbdgs Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	7.14e-02	4.02e-03	6.91e-42	4.63e-11



Evaluating how well caushy_lbd genes are linked to lbdgs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_lbd Exclusive	lbdgs	0.85	1.05	1.29	1.06	2.86
lbdgs Exclusive	caushy_lbd	0.63	1.07	1.37	0.54	5.28
caushy_lbd Exclusive	lbdgs Exclusive	0.81	1.29	1.48	1.02	2.25
lbdgs Exclusive	caushy_lbd Exclusive	0.63	1.01	1.33	0.57	4.92
caushy_lbd Exclusive	Overlap	1.00	1.22	4223664528351.33	1.07	1.54
lbdgs Exclusive	Overlap	0.99	3.69	358648434489119.00	1.79	1.80
Overlap	Exclusives	0.65	inf	3.31	1.90	6.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_lbd Exclusive	lbdgs	0.00	0.06	-7.40	3.06	4.54
lbdgs Exclusive	caushy_lbd	0.01	2.05	2.08	1.11	4.79
caushy_lbd Exclusive	lbdgs Exclusive	0.00	-0.61	-11.33	0.42	0.21
lbdgs Exclusive	caushy_lbd Exclusive	0.01	1.61	1.88	0.96	5.02
caushy_lbd Exclusive	Overlap	0.01	4.68	1835429282098165.00	5.11	2.15
lbdgs Exclusive	Overlap	0.00	32.26	inf	7.84	4.90
Overlap	Exclusives	0.02	898210704148081.00	5.51	2.16	5.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
caushy_lbd Exclusive	150	150	
lbdgs Exclusive	5	5	
Overlap	1	1