Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu-AD_EUR_20K-WES Exclusive	25-GS	2.21e-06	7.96e-06	8.46e-07	1.39e-08
25-GS Exclusive	mu-AD_EUR_20K-WES	4.45e-01	3.29e-01	3.09e-02	1.18e-01
mu-AD_EUR_20K-WES Exclusive	25-GS Exclusive	3.37e-05	4.36e-05	2.98e-06	9.88e-07
25-GS Exclusive	mu-AD_EUR_20K-WES Exclusive	4.72e-01	5.90e-01	2.01e-02	3.73e-01
mu-AD_EUR_20K-WES Exclusive	Overlap	2.37e-02	2.44e-02	8.76e-03	4.32e-04
25-GS Exclusive	Overlap	7.45e-12	7.45e-12	1.57e-10	1.57e-10
Overlap	Exclusives	1.23e-02	1.49e-02	3.90e-10	5.28e-03



Evaluating how well mu-AD_EUR_20K-WES genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-AD_EUR_20K-WES Exclusive	25-GS	0.85	3.16	5.06	3.23	6.47
25-GS Exclusive	mu-AD_EUR_20K-WES	0.54	1.90	1.48	1.69	2.37
mu-AD_EUR_20K-WES Exclusive	25-GS Exclusive	0.82	2.65	4.78	3.01	4.86
25-GS Exclusive	mu-AD_EUR_20K-WES Exclusive	0.53	1.38	1.01	1.05	1.48
mu-AD_EUR_20K-WES Exclusive	Overlap	0.94	2.70	2.75	3.03	3.68
25-GS Exclusive	Overlap	1.00	3.49	3.28	3.17	3.61
Overlap	Exclusives	0.56	1.69	2.57	2.00	3.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-AD_EUR_20K-WES Exclusive	25-GS	0.01	11.39	22.54	12.48	32.59
25-GS Exclusive	mu-AD_EUR_20K-WES	0.02	7.89	8.73	7.15	11.46
mu-AD_EUR_20K-WES Exclusive	25-GS Exclusive	0.01	0.93	20.10	9.75	9.89
25-GS Exclusive	mu-AD_EUR_20K-WES Exclusive	0.01	4.30	2.60	4.03	3.93
mu-AD_EUR_20K-WES Exclusive	Overlap	0.01	5.94	18.55	6.86	1.04
25-GS Exclusive	Overlap	0.06	195.59	110.19	110.45	124.36
Overlap	Exclusives	0.04	22.69	37.30	31.44	38.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu-AD_EUR_20K-WES Exclusive	203	200	;RFPL2;PRAMEF11
25-GS Exclusive	20	19	HLA -DRB1
Overlap	5	5