Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu-AD_HIS_20K-WES Exclusive	25-GS	9.34e-01	7.51e-01	8.56e-01	2.75e-01
25-GS Exclusive	mu-AD_HIS_20K-WES	3.72e-01	5.17e-01	3.42e-01	3.36e-01
mu-AD_HIS_20K-WES Exclusive	25-GS Exclusive	9.91e-01	8.38e-01	9.69e-01	1.75e-01
25-GS Exclusive	mu-AD_HIS_20K-WES Exclusive	3.59e-01	7.17e-01	4.13e-01	3.92e-01
mu-AD_HIS_20K-WES Exclusive	Overlap	6.34e-01	1.98e-02	5.54e-01	3.96e-01
25-GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.27e-02	4.05e-03	6.27e-29	7.35e-04



Evaluating how well mu-AD_HIS_20K-WES genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-AD_HIS_20K-WES Exclusive	25-GS	0.60	-0.01	-0.77	-0.03	1.65
25-GS Exclusive	mu-AD_HIS_20K-WES	0.55	0.39	0.91	0.78	1.32
mu-AD_HIS_20K-WES Exclusive	25-GS Exclusive	0.59	-0.01	-0.36	-0.11	1.68
25-GS Exclusive	mu-AD_HIS_20K-WES Exclusive	0.54	0.25	0.44	0.55	1.15
mu-AD_HIS_20K-WES Exclusive	Overlap	0.82	-0.30	-478776616504535.00	-0.50	1.03
25-GS Exclusive	Overlap	1.00	1.27	111424462830387.00	1.86	1.53
Overlap	Exclusives	0.63	inf	3.90	2.41	4.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-AD_HIS_20K-WES Exclusive	25-GS	0.00	-0.12	-0.87	-0.10	0.71
25-GS Exclusive	mu-AD_HIS_20K-WES	0.00	0.57	0.11	0.89	0.85
mu-AD_HIS_20K-WES Exclusive	25-GS Exclusive	0.00	-0.12	-0.32	-0.15	0.80
25-GS Exclusive	mu-AD_HIS_20K-WES Exclusive	0.00	-0.29	-0.20	-0.02	0.18
mu-AD_HIS_20K-WES Exclusive	Overlap	0.00	-0.55	-2022406143524479.25	-0.64	-0.09
25-GS Exclusive	Overlap	0.02	34.55	32920936630948200.00	89.29	79.99
Overlap	Exclusives	0.01	5503520665877945.00	8.88	8.15	10.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu-AD_HIS_20K-WES Exclusive	68	66	AC004076.1;CCL3L1
25-GS Exclusive	24	23	HLA -DRB1
Overlap	1	1