Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet01 Exclusive	gwas	9.18e-01	7.32e-01	2.51e-05	2.56e-02
gwas Exclusive	wavelet01	3.16e-01	1.33e-01	4.09e-07	6.60e-20
wavelet01 Exclusive	gwas Exclusive	9.26e-01	8.74e-01	1.20e-05	4.79e-02
gwas Exclusive	wavelet01 Exclusive	1.90e-01	1.38e-01	6.49e-08	2.57e-20
wavelet01 Exclusive	Overlap	8.36e-01	3.82e-01	9.38e-02	2.22e-01
gwas Exclusive	Overlap	7.89e-01	7.89e-01	7.89e-01	4.15e-01
Overlap	Exclusives	3.90e-02	2.86e-01	9.89e-53	1.89e-28



Evaluating how well wavelet01 genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet01 Exclusive	gwas	0.60	0.28	-0.65	0.25	3.14
gwas Exclusive	wavelet01	0.71	-0.49	1.35	1.67	10.21
wavelet01 Exclusive	gwas Exclusive	0.59	0.45	-0.52	0.48	2.82
gwas Exclusive	wavelet01 Exclusive	0.71	-0.70	1.45	1.68	8.36
wavelet01 Exclusive	Overlap	0.78	-1.19	-0.50	0.66	1.89
gwas Exclusive	Overlap	0.67	-0.89	-0.51	-0.28	1.09
Overlap	Exclusives	0.72	2.01	2.04	1.61	11.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet01 Exclusive	gwas	0.01	-0.12	-1.72	0.83	3.40
gwas Exclusive	wavelet01	0.02	-0.83	0.68	1.61	11.66
wavelet01 Exclusive	gwas Exclusive	0.01	0.30	-1.24	1.25	3.91
gwas Exclusive	wavelet01 Exclusive	0.02	-1.50	0.00	1.56	6.26
wavelet01 Exclusive	Overlap	0.00	-0.99	-1.47	-0.08	1.15
gwas Exclusive	Overlap	0.02	17.06	85.00	42.70	24.24
Overlap	Exclusives	0.02	0.76	1.69	1.05	10.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet01 Exclusive	157	156	ARL 11.00
gwas Exclusive	74	72	GPNMB;CASC16
Overlap	3	3