Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcswav01	singleton	9.42e-01	8.59e-01	5.96e-01	8.23e-03
singleton	2mcswav01	4.88e-01	7.16e-01	3.13e-06	2.07e-01



Evaluating how well 2mcswav01 genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcswav01	singleton	0.72	0.34	0.92	0.59	3.41
singleton	2mcswav01	0.55	0.33	0.54	0.56	1.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcswav01	singleton	0.00	-0.39	-0.21	0.05	0.96
singleton	2mcswav01	0.01	0.01	0.10	0.43	0.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcswav01	101	101	
singleton	21	21