Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) fcs_PD Exclusive gwas 7.67e-01 7.67e-01 4.06e-01 4.98e-01 gwas Exclusive fcs_PD 5.65e-01 9.95e-01 4.60e-09 1.00e-08 fcs_PD Exclusive gwas Exclusive 8.10e-01 7.44e-01 6.25e-01 3.43e-01 gwas Exclusive fcs_PD Exclusive 3.72e-01 9.89e-01 1.07e-06 1.59e-08 fcs_PD Exclusive Overlap 7.23e-01 4.31e-01 5.20e-02 1.86e-01 gwas Exclusive Overlap 7.52e-01 8.29e-01 9.46e-01 2.96e-01 Overlap Exclusives 2.73e-09 5.30e-03 1.37e-38 1.94e-18 Evaluating how well fcs_PD genes are linked to gwas genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) fcs_PD Exclusive gwas 0.42 0.65 -0.40 -0.81 -1.35 gwas Exclusive fcs_PD 0.58 -0.85 0.24 -0.81 5.48 fcs_PD Exclusive gwas Exclusive 0.39 0.49 -0.57 -0.80 -1.92 gwas Exclusive fcs_PD Exclusive 0.58 -0.90 0.24 -0.91 5.43 fcs_PD Exclusive Overlap 0.84 0.69 1.07 1.06 1.45 gwas Exclusive Overlap 0.71 0.50 0.61 0.38 1.20 Overlap Exclusives 0.64 1.63 3.58 1.54 11.20 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) fcs_PD Exclusive gwas 0.00 0.63 -0.63 -0.61 -0.76 gwas Exclusive fcs_PD 0.02 -1.02 -0.05 -1.10 2.52 fcs_PD Exclusive gwas Exclusive 0.00 0.43 -0.69 -0.75 -1.06 gwas Exclusive fcs_PD Exclusive 0.02 -1.04 -0.03 -1.09 2.66 fcs_PD Exclusive Overlap 0.00 0.37 -0.14 0.16 0.33 gwas Exclusive Overlap 0.00 -0.15 -0.01 -0.32 0.26 Overlap Exclusives 0.03 1.08 2.64 1.10 9.17 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes fcs_PD Exclusive 357 357 gwas Exclusive 25 23 ZN27F543;SSPO Overlap 2 2