Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_PD Exclusive	gwas	7.67e-01	7.67e-01	4.06e-01	4.98e-01
gwas Exclusive	fcs_PD	5.65e-01	9.95e-01	4.60e-09	1.00e-08
fcs_PD Exclusive	gwas Exclusive	8.10e-01	7.44e-01	6.25e-01	3.43e-01
gwas Exclusive	fcs_PD Exclusive	3.72e-01	9.89e-01	1.07e-06	1.59e-08
fcs_PD Exclusive	Overlap	7.23e-01	4.31e-01	5.20e-02	1.86e-01
gwas Exclusive	Overlap	7.52e-01	8.29e-01	9.46e-01	2.96e-01
Overlap	Exclusives	2.73e-09	5.30e-03	1.37e-38	1.94e-18



Evaluating how well fcs_PD genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD Exclusive	gwas	0.42	0.65	-0.40	-0.81	-1.35
gwas Exclusive	fcs_PD	0.58	-0.85	0.24	-0.81	5.48
fcs_PD Exclusive	gwas Exclusive	0.39	0.49	-0.57	-0.80	-1.92
gwas Exclusive	fcs_PD Exclusive	0.58	-0.90	0.24	-0.91	5.43
fcs_PD Exclusive	Overlap	0.84	0.69	1.07	1.06	1.45
gwas Exclusive	Overlap	0.71	0.50	0.61	0.38	1.20
Overlap	Exclusives	0.64	1.63	3.58	1.54	11.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD Exclusive	gwas	0.00	0.63	-0.63	-0.61	-0.76
gwas Exclusive	fcs_PD	0.02	-1.02	-0.05	-1.10	2.52
fcs_PD Exclusive	gwas Exclusive	0.00	0.43	-0.69	-0.75	-1.06
gwas Exclusive	fcs_PD Exclusive	0.02	-1.04	-0.03	-1.09	2.66
fcs_PD Exclusive	Overlap	0.00	0.37	-0.14	0.16	0.33
gwas Exclusive	Overlap	0.00	-0.15	-0.01	-0.32	0.26
Overlap	Exclusives	0.03	1.08	2.64	1.10	9.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_PD Exclusive	357	357	
gwas Exclusive	25	23	ZN27F543;SSPO
Overlap	2	2