Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-familial	1.17e-23	2.64e-16	4.99e-38	6.40e-32
BRCA-familial Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns	1.85e-13	1.44e-11	6.23e-21	2.51e-16
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-familial Exclusive	7.93e-12	3.01e-07	6.34e-21	3.28e-20
BRCA-familial Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	7.32e-10	4.93e-09	5.36e-23	1.61e-13
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	Overlap	1.78e-21	1.78e-21	1.78e-21	1.27e-18
BRCA-familial Exclusive	Overlap	1.78e-21	1.78e-21	1.78e-21	9.80e-20
Overlap	Exclusives	8.03e-14	3.95e-10	3.17e-16	2.64e-19



Evaluating how well FullCohort_BRCA_AllCoreGenes_10xRuns genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-familial	0.99	2.89	7.27	2.92	8.87
BRCA-familial Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns	0.75	2.49	5.42	3.03	10.21
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-familial Exclusive	0.99	2.73	5.93	2.98	6.15
BRCA-familial Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	0.74	2.53	5.09	2.84	8.83
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	Overlap	1.00	2.54	5.70	2.56	5.32
BRCA-familial Exclusive	Overlap	1.00	1.98	4.16	2.77	5.05
Overlap	Exclusives	0.76	4.12	7.85	2.37	10.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-familial	0.25	22.01	267.09	112.71	206.46
BRCA-familial Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns	0.13	39.82	115.87	66.86	187.71
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-familial Exclusive	0.09	4.04	89.57	43.82	359.64
BRCA-familial Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	0.08	34.30	77.59	45.66	117.70
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	Overlap	0.23	104.63	951.06	215.03	952.30
BRCA-familial Exclusive	Overlap	0.16	32.15	335.16	197.70	369.58
Overlap	Exclusives	0.09	61.87	99.94	28.50	128.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	133	133	
BRCA-familial Exclusive	14	14	
Overlap	9	9