Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-gwas	6.95e-02	9.57e-01	1.33e-06	1.27e-05
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns	1.79e-01	8.84e-02	2.55e-12	2.58e-10
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-gwas Exclusive	5.64e-02	9.91e-01	1.80e-05	1.77e-04
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	1.53e-01	1.16e-01	2.72e-11	2.47e-09
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	Overlap	4.90e-07	7.45e-12	7.45e-12	4.61e-08
BRCA-gwas Exclusive	Overlap	2.39e-03	7.20e-04	2.24e-08	3.44e-09
Overlap	Exclusives	1.08e-10	2.45e-09	2.54e-56	1.26e-25



Evaluating how well FullCohort_BRCA_AllCoreGenes_10xRuns genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-gwas	0.62	0.24	0.33	1.76	4.72
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns	0.67	-0.27	0.86	1.23	7.89
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-gwas Exclusive	0.61	-0.08	-0.05	1.30	5.87
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	0.66	-0.56	0.79	1.06	6.64
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	Overlap	0.99	1.94	2.87	2.38	3.67
BRCA-gwas Exclusive	Overlap	0.99	1.75	1.76	2.30	3.89
Overlap	Exclusives	0.71	5.71	7.60	2.78	15.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-gwas	0.02	-0.89	2.10	3.21	4.89
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns	0.02	2.06	9.09	6.10	11.96
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	BRCA-gwas Exclusive	0.01	-1.36	0.02	1.54	3.67
BRCA-gwas Exclusive	FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	0.02	0.29	4.70	3.22	7.27
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	Overlap	0.02	3.22	46.79	23.48	45.44
BRCA-gwas Exclusive	Overlap	0.05	6.27	49.87	29.62	131.57
Overlap	Exclusives	0.05	14.09	28.41	12.12	34.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FullCohort_BRCA_AllCoreGenes_10xRuns Exclusive	137	137	
BRCA-gwas Exclusive	168	168	
Overlap	5	5