Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_EUR_20K-WES_clean2 Exclusive	25-GS	5.27e-10	3.27e-08	4.54e-09	1.78e-10
25-GS Exclusive	EAML_EUR_20K-WES_clean2	2.56e-02	2.88e-02	2.96e-05	2.09e-02
EAML_EUR_20K-WES_clean2 Exclusive	25-GS Exclusive	2.21e-06	1.68e-06	1.37e-05	1.53e-07
25-GS Exclusive	EAML_EUR_20K-WES_clean2 Exclusive	1.12e-01	8.71e-02	3.45e-04	1.56e-01
EAML_EUR_20K-WES_clean2 Exclusive	Overlap	6.39e-08	8.31e-04	1.96e-07	3.96e-07
25-GS Exclusive	Overlap	7.45e-12	7.45e-12	4.47e-11	1.88e-09
Overlap	Exclusives	8.19e-04	3.44e-04	1.26e-14	4.35e-04



Evaluating how well EAML_EUR_20K-WES_clean2 genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EUR_20K-WES_clean2 Exclusive	25-GS	0.87	4.87	6.11	3.63	6.16
25-GS Exclusive	EAML_EUR_20K-WES_clean2	0.56	3.36	3.16	2.86	2.60
EAML_EUR_20K-WES_clean2 Exclusive	25-GS Exclusive	0.84	3.89	5.82	3.16	4.94
25-GS Exclusive	EAML_EUR_20K-WES_clean2 Exclusive	0.55	2.84	2.58	2.23	1.86
EAML_EUR_20K-WES_clean2 Exclusive	Overlap	0.99	4.20	3.41	3.41	3.69
25-GS Exclusive	Overlap	1.00	3.90	3.67	3.39	3.30
Overlap	Exclusives	0.59	2.68	4.85	2.92	4.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EUR_20K-WES_clean2 Exclusive	25-GS	0.03	66.63	88.89	25.88	46.47
25-GS Exclusive	EAML_EUR_20K-WES_clean2	0.03	14.88	36.61	26.37	18.32
EAML_EUR_20K-WES_clean2 Exclusive	25-GS Exclusive	0.02	51.17	61.45	22.18	11.16
25-GS Exclusive	EAML_EUR_20K-WES_clean2 Exclusive	0.02	8.91	19.20	5.25	6.37
EAML_EUR_20K-WES_clean2 Exclusive	Overlap	0.02	60.56	33.69	62.94	6.15
25-GS Exclusive	Overlap	0.08	281.31	260.54	233.91	97.72
Overlap	Exclusives	0.06	66.18	104.26	37.62	80.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_EUR_20K-WES_clean2 Exclusive	138	134	;RFPL2;AL162417.1;PRAMEF11
25-GS Exclusive	20	19	HLA -DRB1
Overlap	5	5