Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_AFR_20K-WES_clean3 Exclusive	25-GS	5.63e-01	2.84e-01	6.11e-01	3.61e-03
25-GS Exclusive	EAML_AFR_20K-WES_clean3	5.91e-01	6.97e-01	1.13e-01	5.06e-01
EAML_AFR_20K-WES_clean3 Exclusive	25-GS Exclusive	7.23e-01	5.72e-01	6.76e-01	1.28e-02
25-GS Exclusive	EAML_AFR_20K-WES_clean3 Exclusive	5.38e-01	8.22e-01	7.60e-02	8.48e-01
EAML_AFR_20K-WES_clean3 Exclusive	Overlap	8.40e-01	4.12e-01	7.38e-01	9.32e-02
25-GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	6.99e-02	1.45e-02	5.22e-18	6.62e-03



Evaluating how well EAML_AFR_20K-WES_clean3 genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_AFR_20K-WES_clean3 Exclusive	25-GS	0.67	0.78	1.64	0.85	3.41
25-GS Exclusive	EAML_AFR_20K-WES_clean3	0.51	1.31	0.17	0.45	0.83
EAML_AFR_20K-WES_clean3 Exclusive	25-GS Exclusive	0.65	0.51	1.19	0.71	2.29
25-GS Exclusive	EAML_AFR_20K-WES_clean3 Exclusive	0.51	1.13	0.09	0.35	0.11
EAML_AFR_20K-WES_clean3 Exclusive	Overlap	0.85	0.86	0.71	1.01	1.90
25-GS Exclusive	Overlap	1.00	2.45	2.27	2.32	2.46
Overlap	Exclusives	0.56	1.54	3.03	1.99	3.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_AFR_20K-WES_clean3 Exclusive	25-GS	0.00	0.05	0.56	0.34	1.37
25-GS Exclusive	EAML_AFR_20K-WES_clean3	0.01	2.84	2.22	1.42	2.65
EAML_AFR_20K-WES_clean3 Exclusive	25-GS Exclusive	0.00	0.20	1.15	0.33	0.90
25-GS Exclusive	EAML_AFR_20K-WES_clean3 Exclusive	0.01	0.64	0.45	0.11	0.08
EAML_AFR_20K-WES_clean3 Exclusive	Overlap	0.00	-0.32	-2.94	-0.32	0.44
25-GS Exclusive	Overlap	0.05	165.65	216.55	130.93	46.66
Overlap	Exclusives	0.02	18.76	18.43	13.21	17.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_AFR_20K-WES_clean3 Exclusive	164	161	AC009879.2;CCDC7;AC126283.2
25-GS Exclusive	23	22	HLA -DRB1
Overlap	2	2