Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_HIS_20K-WES_clean3 Exclusive	25-GS	4.86e-03	5.22e-02	3.02e-02	1.51e-03
25-GS Exclusive	EAML_HIS_20K-WES_clean3	2.44e-01	7.29e-01	2.20e-01	7.33e-01
EAML_HIS_20K-WES_clean3 Exclusive	25-GS Exclusive	2.80e-02	3.94e-02	3.29e-02	4.04e-03
25-GS Exclusive	EAML_HIS_20K-WES_clean3 Exclusive	2.39e-01	7.17e-01	3.09e-01	7.83e-01
EAML_HIS_20K-WES_clean3 Exclusive	Overlap	2.38e-01	1.98e-02	1.98e-01	3.96e-02
25-GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.11e-02	6.20e-03	1.59e-38	3.61e-03



Evaluating how well EAML_HIS_20K-WES_clean3 genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_HIS_20K-WES_clean3 Exclusive	25-GS	0.71	1.70	1.87	1.46	3.99
25-GS Exclusive	EAML_HIS_20K-WES_clean3	0.52	0.74	1.06	1.00	0.48
EAML_HIS_20K-WES_clean3 Exclusive	25-GS Exclusive	0.70	0.98	2.03	1.14	2.73
25-GS Exclusive	EAML_HIS_20K-WES_clean3 Exclusive	0.51	0.85	1.36	0.91	0.69
EAML_HIS_20K-WES_clean3 Exclusive	Overlap	0.98	0.98	-43603640137988.00	0.85	1.64
25-GS Exclusive	Overlap	1.00	1.40	111424462830387.00	1.66	1.76
Overlap	Exclusives	0.58	inf	4.52	2.23	3.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_HIS_20K-WES_clean3 Exclusive	25-GS	0.00	3.42	3.53	1.89	5.43
25-GS Exclusive	EAML_HIS_20K-WES_clean3	0.01	1.38	1.26	2.22	1.53
EAML_HIS_20K-WES_clean3 Exclusive	25-GS Exclusive	0.00	0.78	3.99	1.47	1.61
25-GS Exclusive	EAML_HIS_20K-WES_clean3 Exclusive	0.01	1.29	1.03	1.03	1.62
EAML_HIS_20K-WES_clean3 Exclusive	Overlap	0.00	0.76	-739919259736641.00	0.66	2.04
25-GS Exclusive	Overlap	0.02	23.33	32920936630948200.00	42.35	43.39
Overlap	Exclusives	0.02	3159934990251933.00	9.03	5.31	5.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_HIS_20K-WES_clean3 Exclusive	133	132	
25-GS Exclusive	24	23	HLA -DRB1
Overlap	1	1