Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_EUR_20K-WES_clean2_Z-35 Exclusive	25-GS	2.87e-07	5.32e-06	1.50e-07	1.31e-07
25-GS Exclusive	mu_EUR_20K-WES_clean2_Z-35	1.44e-01	4.19e-01	2.19e-02	2.03e-02
mu_EUR_20K-WES_clean2_Z-35 Exclusive	25-GS Exclusive	2.52e-05	7.73e-05	5.73e-06	3.24e-06
25-GS Exclusive	mu_EUR_20K-WES_clean2_Z-35 Exclusive	2.87e-01	7.18e-01	4.76e-02	7.66e-02
mu_EUR_20K-WES_clean2_Z-35 Exclusive	Overlap	2.44e-05	8.49e-02	1.74e-06	8.71e-06
25-GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.14e-03	2.17e-03	4.89e-15	4.36e-05



Evaluating how well mu_EUR_20K-WES_clean2_Z-35 genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EUR_20K-WES_clean2_Z-35 Exclusive	25-GS	0.83	2.87	4.85	2.92	5.04
25-GS Exclusive	mu_EUR_20K-WES_clean2_Z-35	0.57	1.81	1.62	1.70	3.19
mu_EUR_20K-WES_clean2_Z-35 Exclusive	25-GS Exclusive	0.81	3.31	4.46	3.57	4.78
25-GS Exclusive	mu_EUR_20K-WES_clean2_Z-35 Exclusive	0.56	1.65	0.86	1.53	2.50
mu_EUR_20K-WES_clean2_Z-35 Exclusive	Overlap	0.99	2.58	2.29	2.69	3.02
25-GS Exclusive	Overlap	1.00	2.60	2.32	2.39	3.21
Overlap	Exclusives	0.62	1.92	4.16	2.22	4.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EUR_20K-WES_clean2_Z-35 Exclusive	25-GS	0.02	17.38	34.68	28.85	24.10
25-GS Exclusive	mu_EUR_20K-WES_clean2_Z-35	0.02	14.11	17.99	11.75	20.12
mu_EUR_20K-WES_clean2_Z-35 Exclusive	25-GS Exclusive	0.01	28.46	23.18	13.41	27.95
25-GS Exclusive	mu_EUR_20K-WES_clean2_Z-35 Exclusive	0.01	7.38	6.43	4.46	9.37
mu_EUR_20K-WES_clean2_Z-35 Exclusive	Overlap	0.01	18.29	11.93	32.72	21.09
25-GS Exclusive	Overlap	0.09	221.74	216.03	155.08	314.75
Overlap	Exclusives	0.05	38.76	78.15	37.51	29.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_EUR_20K-WES_clean2_Z-35 Exclusive	119	117	;RFPL2
25-GS Exclusive	22	21	HLA -DRB1
Overlap	3	3