Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_EUR_20K-WES_clean2 Exclusive	25-GS	2.67e-13	6.14e-12	3.15e-13	3.28e-13
25-GS Exclusive	EAML_EUR_20K-WES_clean2	6.73e-03	1.01e-02	6.94e-05	4.89e-03
EAML_EUR_20K-WES_clean2 Exclusive	25-GS Exclusive	6.95e-09	6.25e-09	7.19e-09	2.91e-08
25-GS Exclusive	EAML_EUR_20K-WES_clean2 Exclusive	3.75e-02	5.20e-02	8.17e-05	5.13e-02
EAML_EUR_20K-WES_clean2 Exclusive	Overlap	1.49e-08	1.20e-03	4.90e-07	1.88e-09
25-GS Exclusive	Overlap	7.45e-12	1.88e-09	4.47e-11	4.17e-10
Overlap	Exclusives	6.18e-03	8.46e-04	8.83e-13	1.24e-04



Evaluating how well EAML_EUR_20K-WES_clean2 genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EUR_20K-WES_clean2 Exclusive	25-GS	0.90	4.13	8.06	4.41	6.99
25-GS Exclusive	EAML_EUR_20K-WES_clean2	0.57	4.19	3.27	2.62	3.32
EAML_EUR_20K-WES_clean2 Exclusive	25-GS Exclusive	0.88	4.13	5.92	4.15	5.96
25-GS Exclusive	EAML_EUR_20K-WES_clean2 Exclusive	0.55	3.06	2.39	2.69	2.23
EAML_EUR_20K-WES_clean2 Exclusive	Overlap	0.99	3.62	4.13	3.37	3.62
25-GS Exclusive	Overlap	1.00	3.29	3.39	3.54	4.39
Overlap	Exclusives	0.59	2.92	5.21	2.52	3.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EUR_20K-WES_clean2 Exclusive	25-GS	0.03	33.56	84.80	32.03	34.47
25-GS Exclusive	EAML_EUR_20K-WES_clean2	0.03	35.71	18.29	27.13	24.40
EAML_EUR_20K-WES_clean2 Exclusive	25-GS Exclusive	0.02	39.41	73.43	17.21	18.88
25-GS Exclusive	EAML_EUR_20K-WES_clean2 Exclusive	0.02	14.88	6.35	13.57	15.63
EAML_EUR_20K-WES_clean2 Exclusive	Overlap	0.01	24.08	18.83	15.03	21.64
25-GS Exclusive	Overlap	0.12	252.58	405.57	427.64	601.46
Overlap	Exclusives	0.05	41.38	79.78	38.91	58.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_EUR_20K-WES_clean2 Exclusive	152	149	;AL162417.1;RFPL2
25-GS Exclusive	20	19	HLA -DRB1
Overlap	5	5