Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	25-GS	1.66e-11	3.64e-11	6.61e-12	6.16e-11
25-GS Exclusive	EAML_EUR_20K-WES_clean2_FDR-001	2.73e-01	4.33e-01	8.08e-02	3.42e-01
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	25-GS Exclusive	3.62e-10	6.18e-11	3.75e-10	7.23e-10
25-GS Exclusive	EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	3.21e-01	4.12e-01	1.00e-01	5.12e-01
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	Overlap	9.85e-05	5.91e-04	9.85e-05	5.91e-04
25-GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	6.86e-05	7.48e-06	3.44e-18	3.61e-07



Evaluating how well EAML_EUR_20K-WES_clean2_FDR-001 genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	25-GS	0.87	4.08	7.15	4.84	6.33
25-GS Exclusive	EAML_EUR_20K-WES_clean2_FDR-001	0.53	2.31	1.09	1.11	1.11
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	25-GS Exclusive	0.86	4.18	6.84	4.13	5.58
25-GS Exclusive	EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	0.52	1.96	0.91	1.00	0.52
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	Overlap	0.99	2.51	2.28	2.23	2.40
25-GS Exclusive	Overlap	1.00	2.36	1.96	2.28	2.47
Overlap	Exclusives	0.65	3.19	5.15	2.90	4.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	25-GS	0.02	30.45	79.02	29.05	20.69
25-GS Exclusive	EAML_EUR_20K-WES_clean2_FDR-001	0.02	42.18	33.82	11.71	27.02
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	25-GS Exclusive	0.02	26.83	74.24	32.97	2.87
25-GS Exclusive	EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	0.02	31.69	26.59	5.99	7.84
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	Overlap	0.01	15.79	5.07	22.81	13.14
25-GS Exclusive	Overlap	0.05	147.68	161.67	160.14	32.66
Overlap	Exclusives	0.04	42.87	81.47	25.80	66.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_EUR_20K-WES_clean2_FDR-001 Exclusive	70	67	;RFPL2;AL162417.1
25-GS Exclusive	23	22	HLA -DRB1
Overlap	2	2