Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_mu122_eaml159_117netgen Exclusive	adgs_25_genes	2.78e-13	4.50e-11	9.57e-15	4.36e-13
adgs_25_genes Exclusive	fcs_mu122_eaml159_117netgen	7.88e-04	1.19e-03	7.88e-07	6.90e-08
fcs_mu122_eaml159_117netgen Exclusive	adgs_25_genes Exclusive	6.47e-09	3.54e-08	7.70e-10	1.17e-08
adgs_25_genes Exclusive	fcs_mu122_eaml159_117netgen Exclusive	8.23e-03	4.79e-03	9.72e-06	5.85e-06
fcs_mu122_eaml159_117netgen Exclusive	Overlap	7.45e-12	7.20e-04	7.45e-12	1.57e-10
adgs_25_genes Exclusive	Overlap	7.45e-12	1.49e-08	7.45e-12	1.88e-09
Overlap	Exclusives	7.50e-06	4.21e-08	1.58e-12	8.47e-13



Evaluating how well fcs_mu122_eaml159_117netgen genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_mu122_eaml159_117netgen Exclusive	adgs_25_genes	0.90	4.76	7.56	4.29	8.20
adgs_25_genes Exclusive	fcs_mu122_eaml159_117netgen	0.69	2.37	3.44	2.68	7.06
fcs_mu122_eaml159_117netgen Exclusive	adgs_25_genes Exclusive	0.88	4.85	6.01	4.31	5.80
adgs_25_genes Exclusive	fcs_mu122_eaml159_117netgen Exclusive	0.67	2.77	3.62	2.50	5.41
fcs_mu122_eaml159_117netgen Exclusive	Overlap	1.00	4.07	3.62	3.01	4.43
adgs_25_genes Exclusive	Overlap	1.00	3.93	3.97	3.15	4.18
Overlap	Exclusives	0.73	3.69	6.66	2.84	9.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_mu122_eaml159_117netgen Exclusive	adgs_25_genes	0.04	47.10	67.05	64.12	84.89
adgs_25_genes Exclusive	fcs_mu122_eaml159_117netgen	0.04	30.65	41.59	34.21	59.62
fcs_mu122_eaml159_117netgen Exclusive	adgs_25_genes Exclusive	0.02	33.03	46.60	39.98	42.58
adgs_25_genes Exclusive	fcs_mu122_eaml159_117netgen Exclusive	0.02	18.92	20.84	12.37	10.55
fcs_mu122_eaml159_117netgen Exclusive	Overlap	0.05	81.88	49.86	63.53	115.40
adgs_25_genes Exclusive	Overlap	0.12	394.33	378.36	502.04	532.33
Overlap	Exclusives	0.08	41.02	92.53	48.37	90.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_mu122_eaml159_117netgen Exclusive	112	112	
adgs_25_genes Exclusive	20	19	HLA -DRB1
Overlap	5	5