Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2method_train_72	singleton	6.29e-01	4.05e-01	2.71e-02	4.88e-03
singleton	2method_train_72	4.56e-01	8.68e-01	2.01e-05	4.34e-02



Evaluating how well 2method_train_72 genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2method_train_72	singleton	0.69	-0.53	-0.11	0.44	3.56
singleton	2method_train_72	0.59	0.47	0.37	0.76	2.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2method_train_72	singleton	0.00	-0.51	-0.05	0.75	2.27
singleton	2method_train_72	0.00	0.11	-0.33	0.42	1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2method_train_72	72	72	
singleton	21	21