Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2method_train_72 Exclusive	gwas77	2.76e-01	2.93e-01	1.34e-03	1.19e-03
gwas77 Exclusive	2method_train_72	4.81e-01	3.29e-01	3.35e-03	6.18e-03
2method_train_72 Exclusive	gwas77 Exclusive	3.91e-01	3.73e-01	1.10e-03	1.25e-03
gwas77 Exclusive	2method_train_72 Exclusive	4.00e-01	1.70e-01	2.15e-03	1.61e-03
2method_train_72 Exclusive	Overlap	9.34e-01	9.89e-01	9.89e-01	8.84e-01
gwas77 Exclusive	Overlap	3.82e-01	6.95e-01	9.34e-01	7.13e-01
Overlap	Exclusives	3.51e-02	4.01e-02	2.13e-02	2.40e-06



Evaluating how well 2method_train_72 genes are linked to gwas77 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2method_train_72 Exclusive	gwas77	0.63	1.56	1.80	1.46	3.88
gwas77 Exclusive	2method_train_72	0.62	2.19	1.96	2.15	4.01
2method_train_72 Exclusive	gwas77 Exclusive	0.63	1.59	1.53	1.47	3.86
gwas77 Exclusive	2method_train_72 Exclusive	0.63	2.25	2.39	2.15	3.67
2method_train_72 Exclusive	Overlap	0.45	-0.21	-0.24	-0.39	-0.40
gwas77 Exclusive	Overlap	0.40	-0.76	-0.63	-0.58	-0.62
Overlap	Exclusives	0.63	1.55	3.03	1.85	5.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2method_train_72 Exclusive	gwas77	0.01	0.87	1.17	1.37	3.20
gwas77 Exclusive	2method_train_72	0.01	0.08	0.15	1.23	2.09
2method_train_72 Exclusive	gwas77 Exclusive	0.01	0.95	1.54	1.45	0.61
gwas77 Exclusive	2method_train_72 Exclusive	0.01	0.52	0.56	1.37	3.12
2method_train_72 Exclusive	Overlap	0.00	-0.39	-0.35	-0.46	-0.47
gwas77 Exclusive	Overlap	0.00	-0.64	-0.39	-0.64	-0.66
Overlap	Exclusives	0.01	0.41	1.55	0.74	2.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2method_train_72 Exclusive	69	69	
gwas77 Exclusive	74	73	CASC16
Overlap	3	3