Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 2method_emal_mu singleton 6.55e-01 5.74e-01 8.34e-01 4.73e-02 singleton 2method_emal_mu 2.02e-01 6.83e-01 7.55e-04 7.61e-01 Evaluating how well 2method_emal_mu genes are linked to singleton genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 2method_emal_mu singleton 0.64 -0.52 -0.63 -0.45 2.23 singleton 2method_emal_mu 0.51 -0.14 -0.45 -0.10 0.40 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 2method_emal_mu singleton 0.00 -0.34 -0.40 -0.30 0.69 singleton 2method_emal_mu 0.00 -0.31 -0.62 -0.49 -0.32 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 2method_emal_mu 41 41 singleton 21 21