Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_23genes_train_mu_eaml	singleton	5.74e-01	5.38e-01	2.31e-01	7.87e-03
singleton	2mcs_23genes_train_mu_eaml	6.85e-01	8.64e-01	1.49e-02	6.75e-01



Evaluating how well 2mcs_23genes_train_mu_eaml genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_23genes_train_mu_eaml	singleton	0.71	0.27	0.44	0.54	3.69
singleton	2mcs_23genes_train_mu_eaml	0.55	0.26	0.45	0.72	1.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_23genes_train_mu_eaml	singleton	0.00	0.73	1.31	1.08	3.42
singleton	2mcs_23genes_train_mu_eaml	0.00	0.57	-0.18	0.49	0.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_23genes_train_mu_eaml	23	23	
singleton	21	21