Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_23genes_train_mu_eaml Exclusive	gwas77	1.40e-01	1.51e-01	1.53e-01	2.98e-03
gwas77 Exclusive	2mcs_23genes_train_mu_eaml	1.06e-01	7.70e-02	1.39e-02	5.85e-02
2mcs_23genes_train_mu_eaml Exclusive	gwas77 Exclusive	1.30e-01	1.19e-01	8.46e-02	4.09e-03
gwas77 Exclusive	2mcs_23genes_train_mu_eaml Exclusive	1.00e-01	3.65e-02	5.71e-03	3.43e-02
2mcs_23genes_train_mu_eaml Exclusive	Overlap	2.66e-01	4.31e-01	2.59e-01	7.52e-01
gwas77 Exclusive	Overlap	9.25e-01	8.91e-01	7.92e-01	9.09e-01
Overlap	Exclusives	4.80e-02	2.95e-02	8.53e-02	3.53e-04



Evaluating how well 2mcs_23genes_train_mu_eaml genes are linked to gwas77 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_23genes_train_mu_eaml Exclusive	gwas77	0.63	1.88	2.47	1.50	3.99
gwas77 Exclusive	2mcs_23genes_train_mu_eaml	0.66	2.89	2.98	2.78	2.64
2mcs_23genes_train_mu_eaml Exclusive	gwas77 Exclusive	0.64	2.09	2.13	1.80	4.02
gwas77 Exclusive	2mcs_23genes_train_mu_eaml Exclusive	0.68	3.45	3.82	2.84	2.93
2mcs_23genes_train_mu_eaml Exclusive	Overlap	0.46	0.10	-0.11	0.06	-0.18
gwas77 Exclusive	Overlap	0.48	0.02	0.05	-0.04	-0.13
Overlap	Exclusives	0.63	1.24	3.26	1.25	4.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_23genes_train_mu_eaml Exclusive	gwas77	0.01	3.87	5.49	2.62	6.29
gwas77 Exclusive	2mcs_23genes_train_mu_eaml	0.00	2.03	1.29	1.01	1.14
2mcs_23genes_train_mu_eaml Exclusive	gwas77 Exclusive	0.01	3.86	4.79	2.96	7.14
gwas77 Exclusive	2mcs_23genes_train_mu_eaml Exclusive	0.00	2.25	2.08	1.66	0.83
2mcs_23genes_train_mu_eaml Exclusive	Overlap	0.00	-0.20	-0.34	-0.39	-0.38
gwas77 Exclusive	Overlap	0.00	-0.34	-0.25	-0.26	-0.41
Overlap	Exclusives	0.01	0.70	2.41	0.75	3.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_23genes_train_mu_eaml Exclusive	21	21	
gwas77 Exclusive	75	74	CASC16
Overlap	2	2