Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet01	gp2maybe	3.91e-01	5.01e-01	7.31e-02	1.92e-01
gp2maybe	wavelet01	6.65e-01	4.25e-01	3.14e-12	2.37e-20



Evaluating how well wavelet01 genes are linked to gp2maybe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet01	gp2maybe	0.70	-1.10	-0.15	0.47	1.58
gp2maybe	wavelet01	0.72	0.03	0.59	0.45	8.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet01	gp2maybe	0.00	-0.09	1.27	0.70	0.29
gp2maybe	wavelet01	0.02	0.27	0.06	0.43	7.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet01	160	159	ARL 11.00
gp2maybe	6	6