Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi_106gene_uniqueeur Exclusive	adgs_25_genes	1.62e-12	4.38e-12	1.32e-13	9.00e-14
adgs_25_genes Exclusive	epi_106gene_uniqueeur	1.17e-02	6.40e-02	4.52e-03	1.07e-02
epi_106gene_uniqueeur Exclusive	adgs_25_genes Exclusive	3.34e-12	7.80e-13	1.04e-12	5.15e-13
adgs_25_genes Exclusive	epi_106gene_uniqueeur Exclusive	2.26e-02	8.12e-02	3.17e-03	1.71e-02
epi_106gene_uniqueeur Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
adgs_25_genes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.24e-02	7.78e-04	5.61e-40	3.59e-05



Evaluating how well epi_106gene_uniqueeur genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi_106gene_uniqueeur Exclusive	adgs_25_genes	0.89	4.23	7.62	4.08	6.01
adgs_25_genes Exclusive	epi_106gene_uniqueeur	0.59	4.02	3.00	3.05	3.39
epi_106gene_uniqueeur Exclusive	adgs_25_genes Exclusive	0.88	3.34	5.91	3.97	6.47
adgs_25_genes Exclusive	epi_106gene_uniqueeur Exclusive	0.59	3.62	3.33	3.60	3.31
epi_106gene_uniqueeur Exclusive	Overlap	1.00	1.12	125620155926309.00	1.18	1.80
adgs_25_genes Exclusive	Overlap	1.00	1.24	111424462830387.00	1.69	2.02
Overlap	Exclusives	0.64	258225707341777.00	5.18	2.52	5.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi_106gene_uniqueeur Exclusive	adgs_25_genes	0.05	69.04	185.17	92.39	67.90
adgs_25_genes Exclusive	epi_106gene_uniqueeur	0.02	21.09	5.12	10.41	19.10
epi_106gene_uniqueeur Exclusive	adgs_25_genes Exclusive	0.04	46.29	133.68	60.57	92.13
adgs_25_genes Exclusive	epi_106gene_uniqueeur Exclusive	0.02	17.95	5.21	21.01	7.86
epi_106gene_uniqueeur Exclusive	Overlap	0.03	16.01	inf	35.91	2.25
adgs_25_genes Exclusive	Overlap	0.02	23.50	32920936630948200.00	46.18	80.65
Overlap	Exclusives	0.03	inf	34.07	14.97	31.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi_106gene_uniqueeur Exclusive	105	103	RFPL2;AL162417.1
adgs_25_genes Exclusive	24	23	HLA -DRB1
Overlap	1	1