Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_4ea_AD_uniqueeur Exclusive	adgs_25_genes	7.07e-11	4.20e-10	6.61e-12	6.87e-12
adgs_25_genes Exclusive	2mcs_4ea_AD_uniqueeur	3.67e-02	1.06e-01	2.91e-03	3.85e-03
2mcs_4ea_AD_uniqueeur Exclusive	adgs_25_genes Exclusive	4.44e-09	8.93e-10	1.36e-09	2.97e-09
adgs_25_genes Exclusive	2mcs_4ea_AD_uniqueeur Exclusive	1.54e-01	1.12e-01	7.76e-03	1.14e-02
2mcs_4ea_AD_uniqueeur Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
adgs_25_genes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.75e-04	2.18e-05	6.71e-18	2.86e-07



Evaluating how well 2mcs_4ea_AD_uniqueeur genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_4ea_AD_uniqueeur Exclusive	adgs_25_genes	0.88	4.17	5.67	4.12	6.13
adgs_25_genes Exclusive	2mcs_4ea_AD_uniqueeur	0.60	2.57	2.24	2.50	3.60
2mcs_4ea_AD_uniqueeur Exclusive	adgs_25_genes Exclusive	0.87	3.96	5.72	3.94	5.49
adgs_25_genes Exclusive	2mcs_4ea_AD_uniqueeur Exclusive	0.59	2.45	2.36	2.55	2.70
2mcs_4ea_AD_uniqueeur Exclusive	Overlap	1.00	3.22	2.58	2.98	2.95
adgs_25_genes Exclusive	Overlap	1.00	2.91	2.41	2.60	3.49
Overlap	Exclusives	0.66	2.79	5.75	3.09	5.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_4ea_AD_uniqueeur Exclusive	adgs_25_genes	0.06	59.91	121.22	89.72	47.34
adgs_25_genes Exclusive	2mcs_4ea_AD_uniqueeur	0.03	32.90	17.18	36.28	16.85
2mcs_4ea_AD_uniqueeur Exclusive	adgs_25_genes Exclusive	0.04	44.78	107.88	37.96	5.02
adgs_25_genes Exclusive	2mcs_4ea_AD_uniqueeur Exclusive	0.02	22.14	26.92	15.86	9.61
2mcs_4ea_AD_uniqueeur Exclusive	Overlap	0.03	67.33	88.19	97.46	36.13
adgs_25_genes Exclusive	Overlap	0.09	256.81	223.00	201.78	319.24
Overlap	Exclusives	0.07	24.50	60.56	43.24	35.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_4ea_AD_uniqueeur Exclusive	89	87	AL162417.1;RFPL2
adgs_25_genes Exclusive	22	21	HLA -DRB1
Overlap	3	3