Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cauchy_4ea_unique_105 Exclusive	adgs_25_genes	6.37e-06	2.93e-06	3.93e-10	8.23e-09
adgs_25_genes Exclusive	cauchy_4ea_unique_105	3.68e-02	3.86e-01	1.67e-02	1.16e-04
cauchy_4ea_unique_105 Exclusive	adgs_25_genes Exclusive	4.04e-05	1.49e-05	1.42e-08	3.72e-07
adgs_25_genes Exclusive	cauchy_4ea_unique_105 Exclusive	1.27e-01	6.36e-01	1.15e-02	2.35e-04
cauchy_4ea_unique_105 Exclusive	Overlap	6.42e-02	1.60e-01	1.13e-03	1.43e-03
adgs_25_genes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	1.32e-04	3.75e-05	5.50e-21	6.81e-11



Evaluating how well cauchy_4ea_unique_105 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cauchy_4ea_unique_105 Exclusive	adgs_25_genes	0.83	3.84	5.41	3.22	5.62
adgs_25_genes Exclusive	cauchy_4ea_unique_105	0.63	1.80	1.68	1.45	4.94
cauchy_4ea_unique_105 Exclusive	adgs_25_genes Exclusive	0.82	3.25	4.85	3.09	5.33
adgs_25_genes Exclusive	cauchy_4ea_unique_105 Exclusive	0.62	1.47	1.34	1.29	4.79
cauchy_4ea_unique_105 Exclusive	Overlap	0.97	2.52	1.97	2.37	2.82
adgs_25_genes Exclusive	Overlap	1.00	2.94	2.58	2.32	2.99
Overlap	Exclusives	0.70	2.57	5.48	2.38	8.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cauchy_4ea_unique_105 Exclusive	adgs_25_genes	0.01	11.25	19.74	7.35	12.38
adgs_25_genes Exclusive	cauchy_4ea_unique_105	0.02	14.64	14.38	14.79	10.49
cauchy_4ea_unique_105 Exclusive	adgs_25_genes Exclusive	0.01	10.82	17.61	9.33	19.94
adgs_25_genes Exclusive	cauchy_4ea_unique_105 Exclusive	0.01	6.60	5.76	7.09	4.92
cauchy_4ea_unique_105 Exclusive	Overlap	0.01	9.87	25.09	30.53	5.50
adgs_25_genes Exclusive	Overlap	0.09	316.34	226.21	104.51	28.80
Overlap	Exclusives	0.05	41.29	61.27	29.23	74.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cauchy_4ea_unique_105 Exclusive	102	101	RFPL2
adgs_25_genes Exclusive	22	21	HLA -DRB1
Overlap	3	3