Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_D_uniqueEUR Exclusive	adgs_25_genes	7.46e-08	1.65e-08	1.20e-14	1.11e-11
adgs_25_genes Exclusive	fcs_D_uniqueEUR	4.98e-05	3.05e-03	1.43e-08	1.01e-11
fcs_D_uniqueEUR Exclusive	adgs_25_genes Exclusive	5.02e-05	3.90e-06	2.38e-10	7.45e-08
adgs_25_genes Exclusive	fcs_D_uniqueEUR Exclusive	7.76e-04	1.40e-02	2.50e-07	2.23e-10
fcs_D_uniqueEUR Exclusive	Overlap	1.58e-05	9.56e-04	4.17e-10	8.67e-08
adgs_25_genes Exclusive	Overlap	7.45e-12	5.90e-09	1.88e-09	1.49e-08
Overlap	Exclusives	2.74e-05	3.25e-06	1.48e-19	3.97e-20



Evaluating how well fcs_D_uniqueEUR genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_D_uniqueEUR Exclusive	adgs_25_genes	0.87	4.29	6.53	3.38	5.90
adgs_25_genes Exclusive	fcs_D_uniqueEUR	0.67	2.51	3.99	2.32	10.02
fcs_D_uniqueEUR Exclusive	adgs_25_genes Exclusive	0.84	4.08	5.75	3.88	5.11
adgs_25_genes Exclusive	fcs_D_uniqueEUR Exclusive	0.66	1.96	3.36	2.43	7.66
fcs_D_uniqueEUR Exclusive	Overlap	0.98	4.38	3.75	3.33	3.91
adgs_25_genes Exclusive	Overlap	1.00	3.60	3.29	2.73	3.73
Overlap	Exclusives	0.70	2.80	5.82	2.68	11.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_D_uniqueEUR Exclusive	adgs_25_genes	0.02	21.78	28.49	18.32	23.40
adgs_25_genes Exclusive	fcs_D_uniqueEUR	0.04	15.39	16.83	16.53	37.31
fcs_D_uniqueEUR Exclusive	adgs_25_genes Exclusive	0.01	12.59	16.95	18.62	20.48
adgs_25_genes Exclusive	fcs_D_uniqueEUR Exclusive	0.03	7.49	8.18	9.13	15.12
fcs_D_uniqueEUR Exclusive	Overlap	0.03	56.07	82.08	48.36	170.70
adgs_25_genes Exclusive	Overlap	0.12	348.82	349.16	209.33	107.61
Overlap	Exclusives	0.06	29.61	41.76	25.08	70.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_D_uniqueEUR Exclusive	222	222	
adgs_25_genes Exclusive	20	19	HLA -DRB1
Overlap	5	5