Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet01_pd Exclusive	gp2union	7.75e-01	7.92e-01	2.63e-04	2.26e-03
gp2union Exclusive	wavelet01_pd	3.35e-01	4.38e-03	1.26e-17	6.47e-21
wavelet01_pd Exclusive	gp2union Exclusive	6.02e-01	7.55e-01	9.85e-04	5.13e-03
gp2union Exclusive	wavelet01_pd Exclusive	5.02e-01	1.06e-02	8.54e-17	9.92e-21
wavelet01_pd Exclusive	Overlap	7.92e-02	4.55e-01	1.98e-02	2.77e-01
gp2union Exclusive	Overlap	3.96e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	1.42e-01	7.55e-02	5.43e-40	6.11e-25



Evaluating how well wavelet01_pd genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet01_pd Exclusive	gp2union	0.77	0.93	0.94	1.48	4.08
gp2union Exclusive	wavelet01_pd	0.74	1.53	3.48	2.10	10.53
wavelet01_pd Exclusive	gp2union Exclusive	0.76	1.02	1.13	1.61	3.20
gp2union Exclusive	wavelet01_pd Exclusive	0.74	1.24	2.99	1.96	11.74
wavelet01_pd Exclusive	Overlap	0.88	-2.60	-0.34	0.81	1.27
gp2union Exclusive	Overlap	0.98	1.66	1.78	1.92	1.77
Overlap	Exclusives	0.75	0.72	2.67	2.00	12.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet01_pd Exclusive	gp2union	0.00	-0.20	-1.32	1.37	10.77
gp2union Exclusive	wavelet01_pd	0.02	1.64	2.40	3.12	10.06
wavelet01_pd Exclusive	gp2union Exclusive	0.00	0.00	-1.59	2.31	5.19
gp2union Exclusive	wavelet01_pd Exclusive	0.02	1.04	1.91	3.05	15.40
wavelet01_pd Exclusive	Overlap	0.00	-0.86	-0.83	0.04	0.37
gp2union Exclusive	Overlap	0.00	2.64	14.05	6.80	4.42
Overlap	Exclusives	0.02	0.21	1.33	1.44	13.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet01_pd Exclusive	159	158	ARL 11.00
gp2union Exclusive	15	14	GBNMP
Overlap	1	1