Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eaml_pd Exclusive	gp2union	2.54e-02	6.52e-04	3.52e-02	2.31e-06
gp2union Exclusive	eaml_pd	1.02e-02	8.22e-02	1.39e-22	8.31e-02
eaml_pd Exclusive	gp2union Exclusive	1.71e-01	1.87e-03	1.16e-01	1.14e-05
gp2union Exclusive	eaml_pd Exclusive	2.45e-02	1.21e-01	3.53e-24	1.15e-01
eaml_pd Exclusive	Overlap	9.90e-02	3.17e-01	1.19e-01	4.75e-01
gp2union Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.66e-04	1.57e-02	1.15e-07	9.57e-03



Evaluating how well eaml_pd genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml_pd Exclusive	gp2union	0.82	2.79	3.81	3.05	4.71
gp2union Exclusive	eaml_pd	0.53	2.59	2.06	1.44	1.54
eaml_pd Exclusive	gp2union Exclusive	0.82	1.90	3.61	2.13	4.60
gp2union Exclusive	eaml_pd Exclusive	0.53	2.26	1.88	1.37	1.35
eaml_pd Exclusive	Overlap	0.79	2.77	1.43	2.41	0.95
gp2union Exclusive	Overlap	1.00	27.80	5.64	3.36	1.74
Overlap	Exclusives	0.57	2.42	3.35	1.84	3.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml_pd Exclusive	gp2union	0.00	0.94	0.24	0.89	0.98
gp2union Exclusive	eaml_pd	0.01	3.13	3.63	2.96	3.76
eaml_pd Exclusive	gp2union Exclusive	0.00	0.46	-0.12	0.32	4.35
gp2union Exclusive	eaml_pd Exclusive	0.01	1.98	1.91	1.37	1.20
eaml_pd Exclusive	Overlap	0.00	0.63	0.05	-0.10	-0.11
gp2union Exclusive	Overlap	0.17	154384.82	728.14	51.32	70.19
Overlap	Exclusives	0.02	8.16	12.25	6.10	10.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eaml_pd Exclusive	166	166	
gp2union Exclusive	15	14	GBNMP
Overlap	1	1