Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu-diff_pd Exclusive	gp2union	6.59e-01	4.26e-01	6.77e-01	1.16e-01
gp2union Exclusive	mu-diff_pd	7.54e-01	9.83e-01	6.88e-12	5.96e-01
mu-diff_pd Exclusive	gp2union Exclusive	5.93e-01	4.59e-01	6.15e-01	1.27e-01
gp2union Exclusive	mu-diff_pd Exclusive	7.60e-01	9.75e-01	2.60e-13	5.67e-01
mu-diff_pd Exclusive	Overlap	5.94e-01	6.34e-01	6.73e-01	5.15e-01
gp2union Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.16e-04	7.09e-02	1.49e-05	2.32e-02



Evaluating how well mu-diff_pd genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-diff_pd Exclusive	gp2union	0.67	-0.26	0.32	0.01	2.16
gp2union Exclusive	mu-diff_pd	0.51	1.11	0.29	0.87	0.37
mu-diff_pd Exclusive	gp2union Exclusive	0.67	-0.42	-0.15	-0.26	2.23
gp2union Exclusive	mu-diff_pd Exclusive	0.51	0.73	0.23	0.70	0.34
mu-diff_pd Exclusive	Overlap	0.71	0.77	0.59	0.66	0.76
gp2union Exclusive	Overlap	1.00	2.69	1.48	2.09	1.75
Overlap	Exclusives	0.54	1.14	1.71	1.14	1.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-diff_pd Exclusive	gp2union	0.00	0.82	1.08	0.79	3.27
gp2union Exclusive	mu-diff_pd	0.01	0.98	0.58	1.08	0.54
mu-diff_pd Exclusive	gp2union Exclusive	0.00	1.20	1.06	1.14	1.79
gp2union Exclusive	mu-diff_pd Exclusive	0.01	0.14	0.16	0.57	0.42
mu-diff_pd Exclusive	Overlap	0.00	0.00	-0.19	0.04	-0.10
gp2union Exclusive	Overlap	0.01	29.81	20.69	12.17	10.75
Overlap	Exclusives	0.01	2.38	3.63	2.04	3.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu-diff_pd Exclusive	158	158	
gp2union Exclusive	15	14	GBNMP
Overlap	1	1