Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_359_pd Exclusive	gp2union	2.31e-01	2.00e-01	6.09e-04	1.02e-04
gp2union Exclusive	fcs_359_pd	9.76e-02	3.03e-04	1.00e-39	2.95e-17
fcs_359_pd Exclusive	gp2union Exclusive	1.40e-01	4.04e-02	3.78e-03	5.64e-04
gp2union Exclusive	fcs_359_pd Exclusive	1.15e-01	4.95e-04	3.74e-39	3.31e-17
fcs_359_pd Exclusive	Overlap	7.22e-01	7.04e-01	1.23e-01	4.76e-01
gp2union Exclusive	Overlap	4.36e-06	4.97e-04	2.44e-05	3.56e-04
Overlap	Exclusives	7.68e-03	4.05e-03	1.87e-10	8.05e-20



Evaluating how well fcs_359_pd genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_359_pd Exclusive	gp2union	0.82	2.70	2.73	1.97	4.72
gp2union Exclusive	fcs_359_pd	0.65	3.19	4.36	2.59	9.25
fcs_359_pd Exclusive	gp2union Exclusive	0.84	1.51	2.33	2.00	4.44
gp2union Exclusive	fcs_359_pd Exclusive	0.65	2.86	3.66	2.36	9.32
fcs_359_pd Exclusive	Overlap	0.74	2.51	1.70	1.48	1.32
gp2union Exclusive	Overlap	0.99	7.19	4.05	3.57	2.82
Overlap	Exclusives	0.65	1.13	3.99	1.85	11.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_359_pd Exclusive	gp2union	0.01	3.28	-26.85	4.03	10.67
gp2union Exclusive	fcs_359_pd	0.03	4.74	6.10	5.80	11.84
fcs_359_pd Exclusive	gp2union Exclusive	0.01	3.29	-46.59	6.09	12.15
gp2union Exclusive	fcs_359_pd Exclusive	0.03	3.80	4.36	4.54	11.95
fcs_359_pd Exclusive	Overlap	0.00	0.28	-0.13	0.75	0.02
gp2union Exclusive	Overlap	0.06	421.62	163.07	184.42	54.38
Overlap	Exclusives	0.03	2.32	5.93	3.34	13.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_359_pd Exclusive	356	356	
gp2union Exclusive	13	12	GBNMP
Overlap	3	3