Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_359_pd Exclusive	gp2	2.79e-01	1.80e-01	1.02e-03	8.34e-05
gp2 Exclusive	fcs_359_pd	7.81e-02	8.97e-04	5.71e-72	2.06e-17
fcs_359_pd Exclusive	gp2 Exclusive	3.11e-01	1.41e-01	9.75e-03	1.21e-04
gp2 Exclusive	fcs_359_pd Exclusive	1.64e-01	1.02e-03	3.40e-81	5.94e-18
fcs_359_pd Exclusive	Overlap	7.13e-01	7.22e-01	1.23e-01	3.74e-01
gp2 Exclusive	Overlap	5.23e-05	7.19e-05	3.66e-05	5.23e-05
Overlap	Exclusives	3.72e-03	7.89e-03	1.20e-08	9.00e-19



Evaluating how well fcs_359_pd genes are linked to gp2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_359_pd Exclusive	gp2	0.87	3.46	3.09	2.50	4.55
gp2 Exclusive	fcs_359_pd	0.66	2.28	5.37	1.78	9.89
fcs_359_pd Exclusive	gp2 Exclusive	0.93	2.30	2.98	2.14	4.39
gp2 Exclusive	fcs_359_pd Exclusive	0.65	1.94	4.47	2.23	9.66
fcs_359_pd Exclusive	Overlap	0.74	2.48	1.48	1.91	1.44
gp2 Exclusive	Overlap	0.99	23.77	3.75	4.90	2.82
Overlap	Exclusives	0.65	1.03	3.17	1.53	9.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_359_pd Exclusive	gp2	0.01	2.40	-55.75	3.64	2.03
gp2 Exclusive	fcs_359_pd	0.03	4.67	9.02	3.67	13.07
fcs_359_pd Exclusive	gp2 Exclusive	0.01	1.80	-98.04	3.89	7.71
gp2 Exclusive	fcs_359_pd Exclusive	0.03	3.83	6.80	4.23	13.24
fcs_359_pd Exclusive	Overlap	0.00	0.56	0.04	0.74	0.09
gp2 Exclusive	Overlap	0.03	169.81	75.71	175.36	112.19
Overlap	Exclusives	0.03	1.47	4.20	2.17	10.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_359_pd Exclusive	356	356	
gp2 Exclusive	7	6	GBNMP
Overlap	3	3