Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_359_pd	gp2maybe	4.31e-01	4.55e-01	6.24e-02	6.24e-02
gp2maybe	fcs_359_pd	7.36e-03	1.91e-02	1.40e-27	3.22e-16



Evaluating how well fcs_359_pd genes are linked to gp2maybe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_359_pd	gp2maybe	0.79	0.97	1.51	1.51	2.67
gp2maybe	fcs_359_pd	0.64	2.33	3.22	1.65	8.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_359_pd	gp2maybe	0.00	4.93	6.15	6.11	2.48
gp2maybe	fcs_359_pd	0.03	3.13	2.14	2.27	8.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_359_pd	359	359	
gp2maybe	6	6