Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_101_pd	gp2maybe	7.49e-01	8.88e-01	9.02e-01	3.06e-01
gp2maybe	2mcs_101_pd	1.87e-01	5.93e-01	4.96e-08	6.44e-02



Evaluating how well 2mcs_101_pd genes are linked to gp2maybe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_101_pd	gp2maybe	0.68	-0.36	0.50	0.40	1.52
gp2maybe	2mcs_101_pd	0.57	1.74	0.91	1.18	2.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_101_pd	gp2maybe	0.00	0.02	1.78	0.46	0.12
gp2maybe	2mcs_101_pd	0.01	1.33	0.34	0.84	0.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_101_pd	101	101	
gp2maybe	6	6