Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_101_pd	gp2	7.56e-01	7.50e-01	7.94e-01	5.73e-02
gp2	2mcs_101_pd	1.22e-01	8.70e-02	1.59e-17	4.22e-03



Evaluating how well 2mcs_101_pd genes are linked to gp2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_101_pd	gp2	0.73	0.27	0.73	0.66	2.18
gp2	2mcs_101_pd	0.56	0.51	1.01	1.00	2.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_101_pd	gp2	0.00	-0.29	-0.75	0.07	1.48
gp2	2mcs_101_pd	0.01	0.23	0.25	0.46	1.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_101_pd	101	101	
gp2	10	9	GBNMP