Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_101_pd	gp2union	8.04e-01	7.63e-01	6.28e-01	3.57e-02
gp2union	2mcs_101_pd	5.98e-01	4.07e-01	4.41e-11	3.37e-02



Evaluating how well 2mcs_101_pd genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_101_pd	gp2union	0.71	-0.19	0.84	0.78	2.42
gp2union	2mcs_101_pd	0.57	0.55	0.63	1.25	2.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_101_pd	gp2union	0.00	-0.21	0.18	0.63	0.07
gp2union	2mcs_101_pd	0.01	0.59	-0.12	0.88	1.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_101_pd	101	101	
gp2union	16	15	GBNMP