Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
caushy_pd	gp2maybe	5.49e-01	4.31e-01	2.82e-02	4.70e-02
gp2maybe	caushy_pd	1.50e-02	6.62e-02	5.05e-15	3.84e-14



Evaluating how well caushy_pd genes are linked to gp2maybe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_pd	gp2maybe	0.78	1.01	1.46	1.57	2.45
gp2maybe	caushy_pd	0.68	1.46	1.76	1.25	6.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_pd	gp2maybe	0.00	2.04	6.88	3.31	3.83
gp2maybe	caushy_pd	0.01	2.46	1.85	1.75	7.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
caushy_pd	161	161	
gp2maybe	6	6